Hydrochlorothiazide (HCTZ) is a sulfonamide-containing drug with commonly reported adverse effects that include electrolyte abnormalities, orthostatic hypotension, hyperglycemia, and photosensitivity.
Can patients with sulfa allergy take hydrochlorothiazide?
Yep, these are safe if you have a sulfa allergy. Thiazide diuretics like chlorthalidone and hydrochlorothiazide (HCTZ) are used to treat high blood pressure and are fine to take even if you’ve been told you have a sulfa allergy to Bactrim.
What diuretics are safe with sulfa allergy?
Diuretics that do not contain a sulfonamide group (eg, amiloride hydrochloride, eplerenone, ethacrynic acid, spironolactone, and triamterene) are safe for patients with an allergy to sulfa.
Why are thiazides contraindicated with sulfa allergy?
Allergists are consulted about the question of hypersensitivity to loop or thiazide diuretics in patients with a history of sulfonamide allergy because it is thought that there is a risk of cross-reactivity from common sulfonamide constituents of these compounds.
What are allergic reactions to hydrochlorothiazide?
What are the possible side effects of hydrochlorothiazide? Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Does spironolactone contain sulfa?
Diuretics that do not contain a sulfonamide group (eg, amilodde hydrochloride, eplerenone, ethacrynic acid, spironolactone, and triamterene) are safe for patients with an allergy to sulfa.
What drugs should be avoided with sulfa allergy?
Drugs to Avoid With Sulfa Allergies
Sulfamethoxazole / trimethoprim (Bactrim, Sulfatrim), a sulfa combination drug that can be taken in liquid or pill form for many types of infections.Sulfacetamide (BLEPH-10), drops for eye infections.Sulfadiazine silver (Silvadene), a cream to prevent and treat burn infections.
What pregnancy category is hydrochlorothiazide?
Hydrochlorothiazide / methyldopa Pregnancy Warnings
US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Is chlorthalidone sulfa based?
The pharmacist reports that the drug interaction system is flagging the chlorthalidone as a problem due to ED’s allergy to SMX since chlorthalidone also contains a sulfa moiety.
Can you give Lasix with a sulfa allergy?
For most patients with sulfa allergy who have no his- tory of life-threatening reactions and are not allergic to more than one class of sulfonamides, however, avail- able evidence suggests that furosemide can be used safely in an emergency.
Can you be allergic to spironolactone?
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Is Zpack a sulfa drug?
Zithromax and Bactrim belong to different antibiotic drug classes. Zithromax is a macrolide antibiotic and Bactrim is a combination of a sulfonamide antibiotic (a “sulfa” drug) and a folic acid inhibitor.
Do all loop diuretics have sulfa?
A look at Table 1 shows that most diuretic agents are sulfonamide derivatives. The only diuretics that are not are the potassium-sparing diuretics (triamterene, spironolactone, and amiloride) and ethacrynic acid.
Do loop diuretics contain sulfa?
1,3,4 Ethacrynic acid is the only loop diuretic on the US market that does not contain a sulfonamide sub- stituent. Unfortunately, the sole US producer of ethacrynic acid (Ede- crin; Merck & Co, West Point, Pa) is currently unable to provide this drug; in fact, it has stopped produc- tion of the oral form indefinitely.
Who should not take hydrochlorothiazide?
a type of joint disorder due to excess uric acid in the blood called gout. low amount of magnesium in the blood. high amount of calcium in the blood. low amount of sodium in the blood.
Is there an alternative to hydrochlorothiazide?
If there were alternative diuretics, why prescribe HCTZ? Chlorthalidone is often offered as an alternative to HCTZ, but has limited pharmaceutical formulations.
Can hydrochlorothiazide cause angioedema?
HCTZ was the definite cause of angioedema in this patient based on a score of 9 on the 10-point Naranjo adverse drug reaction probability scale.
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